1. Health
You can opt-out at any time. Please refer to our privacy policy for contact information.

The Difference Between Sepsis and Septic Shock


Updated May 29, 2014

Written or reviewed by a board-certified physician. See About.com's Medical Review Board.

close-up of surgeons hands making an incision in a patient
Stockbyte/Getty Images
Question: The Difference Between Sepsis and Septic Shock
What is the difference between sepsis and septic shock?

Sepsis is the name given to a blood infection typically caused by bacteria. Sepsis is also known as a blood poisoning, bacteremia, and septicemia. This condition is an infection that is present in the blood and becomes a systemic problem.

Sepsis can start with almost any type of infection, ranging from minor infections (urinary tract infection, abscessed tooth) to serious ones (meningitis). Some patients who become septic were completely unaware of their initial infection. With a typical infection, the body responds to the threat of infection, keeping the infection at the site of origin. Treatment with antibiotics is typically the first course of treatment if the body needs the additional help. When the body is unable to contain the infection in the original site, it can spread in the blood, which is sepsis.

Septic shock is the condition that results from uncontrolled sepsis, and includes extremely low blood pressure, a rapid heart rate, altered mental status, and the need for a ventilator. Septic shock is life-threatening and requires immediate attention. Patients who have septic shock are typically treated in the ICU where they can have around-the-clock care.

Sepsis is more common after surgery for several reasons. First, urinary tract infections are more common after surgery, and these infections can lead to sepsis. Second, an incision is an opening into the body through which infection can begin. Surgery takes a toll on the body and weakens the immune system, even if the procedure is a minor one, which can make infections more likely.

It is important to remember that not all infections will become sepsis, and even fewer will become septic shock. Many infections are so minor that we may not even realize we have them, and the vast majority of infections that require treatment respond very well to antibiotics. After surgery, it is imperative to be mindful of the signs and symptoms of infection.

Unfortunately, while rare, sepsis and septic shock can attack the young and the healthy. It is not uncommon for someone to seem completely well and normal one day, and be incredibly sick with sepsis, or even septic shock, 48 hours later. The risk of death is significant if sepsis leads to septic shock, with approximately 40% of septic shock patients dying, even with treatment.


Sepsis and Septic Shock. Merck Manual of Medical Information, 2nd Home Edition. Accessed March, 2011. http://www.merckmanuals.com/home/print/sec17/ch191/ch191c.html

  1. About.com
  2. Health
  3. Surgery
  4. After Surgery
  5. Difference Between Sepsis Infection and Septic Shock

©2014 About.com. All rights reserved.

We comply with the HONcode standard
for trustworthy health
information: verify here.